Print this page.
Sample Required 7. In resistant patients, increasing the azathioprine dose is not helpful and further increases 6MMPN levels predisposing toward hepatotoxicity. The immunosuppressive effect of thiopurine drugs is mediated primarily by the cytotoxic metabolite, 6-TGN and incorporation of these non functioning bases into DNA.
Time of sampling need not be related to the time of administration of the parent drug. Full details of referral laboratory available on request.
Treating patients with low TPMT activity Suspected non-compliance or treatment with a suboptimal dose Failure to respond to standard doses of thiopurine drugs Please note: Please provide details of current thiopurine drug regime and patient diagnosis on the request form. Please note: Measurement of 6MMPN helps to distinguish patients who are under-dosed or non-compliant 6MMPN levels appropriately low from those demonstrating resistance to thiopurine drugs, i.
Samples must not have been frozen.
The accumulation of high levels of 6-TGN is also responsible for some side effects of thiopurine drugs and has been associated with leucopenia. Clinical Indications Treating patients with low TPMT activity Suspected non-compliance or treatment with a suboptimal dose Failure to respond to standard doses of thiopurine drugs Please note: