These data suggest that pseudohyperkalemia due to thrombocytosis does not occur if plasma samples are used, but can occur if serum samples are used.
Reverse pseudohyperkalemia in heparin plasma samples from a patient with chronic lymphocytic leukemia. Buffy coat is present in spun plasma specimen right but absent in spun serum specimen left.
We also detected atrial fibrillation without rapid ventricular response and treated it with metoprolol. The regulation of extracellular potassium concentration is critical for life. Immediate testing of whole blood with blood gas analyzers at the bedside demonstrated significantly lower potassium concentrations, compared with pneumatic tube—delivered whole blood specimens that were tested in the core laboratory Table 2.
Fluctuations in extracellular potassium, particularly hyperkalemia, affect cell membrane potential and can trigger fatal arrhythmias. Receive exclusive offers and updates from Oxford Academic. Robert C.
These two causes of pseudohyperkalemia extreme leukocytosis and extreme thrombocytosis are the focus of this recently published clinical study. Reverse pseudohyperkalemia is a term used to describe in vitro, falsely elevated potassium concentrations in plasma specimens that occur in association with extreme leukocytosis and are commonly associated with hematologic malignant neoplasms. Difference between plasma and whole-blood potassium was more significantly affected by increasing white cell count 0.
You are commenting using your Twitter account. You are commenting using your WordPress. A commonly used type of ion-selective membrane for potassium is a polyvinyl chloride membrane incorporated with valinomycin. Based on these findings, we diagnosed the patient with tumor lysis syndrome and acute on chronic kidney injury.
Throughout the entire hospitalization of the patient, his WBC count was greater than 100,000 cells per mm 3. Serum and plasma are distinguished by the presence or absence of clotting factors, and pseudohyperkalemia is believed to be caused by potassium release from activated platelets during clot formation in serum. Serum samples contains potassium released by platelets which are separated out in the phlebotomy tube so is usually 0.
Clin Biochem 2017; 50: Blood gases to evaluate possible acidosis. A prospective study of causes of haemolysis during venepuncture: His subsequent potassium concentrations in whole blood remained elevated even after hemodialysis; however, his serum potassium concentrations were decreased.
Split View Views. The patient initially was diagnosed as having tumor lysis syndrome.